研究論文

腸の奥からの健康を考える研究所での取り組みの関連論文についての基本情報と参照先URLを掲載しております。

• すべて
• 大腸ラボ
• スーパー大麦
• イヌリン

• 大腸ラボ

  【A-1】From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

  Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell 2016; 165: 1332-1345.
• 大腸ラボ

  【A-2】Gut Microbial Metabolites Fuel Host Antibody Responses.

  Kim M, Qie Y, Park J, Kim CH. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host Microbe 2016; 20: 202-14.
• 大腸ラボ

  【A-3】Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification

  Sorbara M T, Dubin K, Littmann E R, Moody T U, Fontana E, Seok R et al. Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification J Exp Med 2019; 216: 84–98.
• 大腸ラボ

  【A-4】Gut Microbiota and Cardiovascular Uremic Toxicities.

  Velasquez M T, Centron P, Barrows I, Dwivedi R, Raj D S. Gut Microbiota and Cardiovascular Uremic Toxicities. Toxins (Basel) 2018; 10: 287.
• 大腸ラボ

  【A-5】The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get.

  Yang J, Yu J. The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get. Protein Cell 2018; 9: 474-487.
• 大腸ラボ

  【A-6】Microbial ecology: human gut microbes associated with obesity.

  Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-3.
• 大腸ラボ

  【A-7】Richness of human gut microbiome correlates with metabolic markers.

  Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, et al. Richness of human gut microbiome correlates with metabolic markers. Nature 2013; 500: 541-6.
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  【A-8】The composition of the gut microbiota shapes the colon mucus barrier.

  Jakobsson HE, Rodríguez-Piñeiro AM, Schütte A, Ermund A, Boysen P, Bemark M, et al. The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep 2015; 16: 164-77.
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  【A-9】MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

  Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, et al. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells. Science 2015; 349: 989-93.
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  【A-10】Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes.

  Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, et al. Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes. Diabetes Care 2014; 37: 2343-50.
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  【A-11】Human gut microbes impact host serum metabolome and insulin sensitivity.

  Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 2016; 535: 376-81.
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  【A-12】Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

  Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575-84.
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  【A-13】The microbiome, cancer, and cancer therapy.

  Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA. The microbiome, cancer, and cancer therapy. Nat Med 2019; 25: 377-388.
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  【A-14】The gut microbiome and liver cancer: mechanisms and clinical translation.

  Yu LX, Schwabe RF. The gut microbiome and liver cancer: mechanisms and clinical translation. Nat Rev Gastroenterol Hepatol 2017; 14: 527-539.
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  【A-15】Mental health: thinking from the gut.

  Schmidt C. Mental health: thinking from the gut. Nature 2015; 518: S12-5.
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  【A-16】Gut microbial metabolites in depression: understanding the biochemical mechanisms.

  Caspani G, Kennedy S, Foster JA, Swann J. Gut microbial metabolites in depression: understanding the biochemical mechanisms. Microb Cell 2019; 6: 454-481.
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  【A-17】Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

  Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013; 155: 1451-63.
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  【A-18】Gut microbiome composition is associated with temperament during early childhood.

  Christian LM, Galley JD, Hade EM, Schoppe-Sullivan S, Kamp Dush C, Bailey MT. Gut microbiome composition is associated with temperament during early childhood. Brain Behav Immun 2015; 45: 118-27.
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  【A-19】(Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease.

  Buford T W. (Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease. Microbiome 2017; 5: 80.
• 大腸ラボ

  【A-20】食物繊維摂取量と死亡リスクの関連　―多目的コホート研究（JPHC研究）からの成果報告―

  国立研究開発法人 国立がん研究センター 社会と健康研究センター 予防研究グループ．食物繊維摂取量と死亡リスクの関連 ―多目的コホート研究（JPHC研究）からの成果報告―．2020 No.348
• 大腸ラボ

  【A-21】Effects of probiotics, prebiotics, and synbiotics on human health.

  Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017; 9: 1021.
• スーパー大麦

  【B-1】A systematic review and meta-analysis of randomized controlled trials of the effect of barley β-glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reduction(i-iv).

  Ho H V, Sievenpiper J L, Zurbau A, Blanco Mejia S, Jovanovski E, Au-Yeung F, et al. A systematic review and meta-analysis of randomized controlled trials of the effect of barley β-glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reduction(i-iv). Eur J Clin Nutr 2016; 70: 1239-1245.
• スーパー大麦

  【B-2】Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products.

  Tosh S M. Review of human studies investigating the post-prandial blood-glucose lowering ability of oat and barley food products. Eur J Clin Nutr 2013; 67: 310-7.
• スーパー大麦

  【B-3】The impact of dietary fiber on gut microbiota in host health and disease.

  Makki K, Deehan E C, Walter J, Bäckhed F. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe 2018; 23: 705-715.
• スーパー大麦

  【B-4】Barley sex6 mutants lack starch synthase IIa activity and contain a starch with novel properties.

  Morell M K, Kosar‐Hashemi B, Cmiel M, Samuel M S, Chandler P, Rahman S, et al. Barley sex6 mutants lack starch synthase IIa activity and contain a starch with novel properties. Plant J 2003; 34: 173-185.
• スーパー大麦

  【B-5】Gene expression in a starch synthase IIa mutant of barley: changes in the level of gene transcription and grain composition.

  Clarke B, Liang R, Morell M K, Bird A R, Jenkins C L D, Li Z. Gene expression in a starch synthase IIa mutant of barley: changes in the level of gene transcription and grain composition. Funct Integr Genomics 2008; 8: 211-221.
• スーパー大麦

  【B-6】Effects of BARLEYmax and High-β-Glucan Barley Line on Short-Chain Fatty Acids Production and Microbiota From the Cecum to the Distal Colon in Rats.

  Aoe S, Yamanaka C, Fuwa M, Tamiya T, Nakayama Y, Miyoshi T, et al. Effects of BARLEYmax and High-β-Glucan Barley Line on Short-Chain Fatty Acids Production and Microbiota From the Cecum to the Distal Colon in Rats. PLoS One 2019; 14: e0218118.
• スーパー大麦

  【B-7】Effects of meals with high soluble fibre, high amylose barley variant on glucose, insulin, satiety and thermic effect of food in healthy lean women.

  Keogh J B, Lau C W H, Noakes M, Bowen J, Clifton P M. Effects of meals with high soluble fibre, high amylose barley variant on glucose, insulin, satiety and thermic effect of food in healthy lean women. Eur J Clin Nutr 2007; 61: 597-604.
• スーパー大麦

  【B-8】An extruded breakfast cereal made from a high amylose barley cultivar has a low glycemic index and lower plasma insulin response than one made from a standard barley.

  King R A, Noakes M, Bird A R, Morell M K, Topping D L. An extruded breakfast cereal made from a high amylose barley cultivar has a low glycemic index and lower plasma insulin response than one made from a standard barley. J Cereal Sci 2008; 48: 526-530.
• スーパー大麦

  【B-9】Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects.

  Bird A　R, Vuaran M　S, King R　A, Noakes M, Keogh J, Morell M　K, et al. Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects. Br J Nutr 2008; 99: 1032-40.
• スーパー大麦

  【B-10】機能性大麦BARLEYmax (Tantangara) による整腸効果についてーランダム化二重盲検並行群間比較試験―

  北薗英一, 妹脊和男, 松井輝明. 機能性大麦BARLEYmax (Tantangara) による整腸効果についてーランダム化二重盲検並行群間比較試験―. 薬理と治療 2016; 44: 1785-93.
• スーパー大麦

  【B-11】機能性大麦BARLEYmax(Tantangara)による整腸効果について－ランダム化二重盲検並行群間比較試験－．

  西村文，北薗英一，妹脊和男，瓜田純久，松井輝明． 機能性大麦BARLEYmax(Tantangara)による整腸効果について－ランダム化二重盲検並行群間比較試験－． 薬理と治療 2017; 45: 1047-55.
• スーパー大麦

  【B-12】機能性大麦BARLEYmax（Tantangara） 経口摂取による睡眠改善効果について．

  北薗英一，西村文，妹脊和男，森田英利． 機能性大麦BARLEYmax（Tantangara） 経口摂取による睡眠改善効果について． 薬理と治療 2017; 45: 1351-7.
• スーパー大麦

  【B-13】機能性大麦BARLEYmax (Tantangara)の腸内細菌叢を介する抗肥満効果 －ランダム化二重盲検プラセボ対照並行群間比較法－

  野村直生，西村文，三好孝則，北薗英一，森田英利，松井輝明． 機能性大麦BARLEYmax (Tantangara)の腸内細菌叢を介する抗肥満効果 －ランダム化二重盲検プラセボ対照並行群間比較法－ 薬理と治療 2018; 46: 2099-110.
• スーパー大麦

  【B-14】Glycemic index of boiled BARLEYmax® in healthy Japanese subjects.

  Nomura N, Miyoshi T, Hamada Y, Kitazono E. Glycemic index of boiled BARLEYmax® in healthy Japanese subjects. J Cereal Sci 2020; 93: 102959.
• イヌリン

  【C-1】Comparison of the prebiotic properties of native chicory and synthetic inulins using swine fecal cultures.

  Nakayama Y, Kawasaki N, Tamiya T, Anzai S, Toyohara K, Nishiyama A & Kitazono E. Comparison of the prebiotic properties of native chicory and synthetic inulins using swine fecal cultures. Biosci Biotechnol Biochem 2020; 1749553.
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  【C-2】Dietary fructooligosaccharides affect intestinal barrier function in healthy men.

  Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, van der Meer R. Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J Nutr 2006; 136: 70-4.
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  【C-3】A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans.

  Kolida S, Meyer D, Gibson GR. A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. Eur J Clin Nutr 2007; 61: 1189-95.
• イヌリン

  【C-4】Effect of high performance chicory inulin on constipation.

  Den Hond E, Geypens B, Ghoos Y. Effect of high performance chicory inulin on constipation. Nutrition Research 2000; 20: 731-6.
• イヌリン

  【C-5】イヌリン添加米粉食パンの排便習慣改善効果．

  小枝貴弘，原健二郎，和田正，森田達也，新井映子． イヌリン添加米粉食パンの排便習慣改善効果． 薬理と治療 2015; 43: 1731-1737.
• イヌリン

  【C-6】Effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes.

  Pourghassem Gargari B, Dehghan P, Aliasgharzadeh A, Asghari Jafar-Abadi M. Effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes. Diabetes Metab J 2013; 37: 140-8.
• イヌリン

  【C-7】Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial.

  Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition 2014; 30: 418-23.
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  【C-8】Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men.

  Coudray C, Bellanger J, Castiglia-Delavaud C, Rémésy C, Vermorel M, Rayssignuier Y. Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr 1997; 51: 375-80.
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  【C-9】Dietary Fiber Confers Protection against Flu by Shaping Ly6c(-) Patrolling Monocyte Hematopoiesis and CD8(+) T Cell Metabolism.

  Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E, Pernot J, et al. Dietary Fiber Confers Protection against Flu by Shaping Ly6c(-) Patrolling Monocyte Hematopoiesis and CD8(+) T Cell Metabolism. Immunity 2018; 48: 992-1005.
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  【C-10】Supplementation of baby formula with native inulin has a prebiotic effect in formula-fed babies.

  Kim SH, Lee DH, Meyer D. Supplementation of baby formula with native inulin has a prebiotic effect in formula-fed babies. Asia Pac J Clin Nutr 2007; 16: 172-7.